5-叔丁基噻吩-2-羧酸合成路线 （共 10 条）
反应条件
1: With sodium hydroxide; water in methanol 3 h; Heating / reflux; 2: With hydrogenchloride in methanol; water; ethyl acetate pH=3;
参考文献
Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Paulsen, Holger; Riedl, Bernd; Scott, William J.; Smith, Roger A.; Wood, Jill; Hatoum-Mokdad, Holia; Lee, Wendy; Redman, Aniko; Johnson, Jeffrey; Sibley, Robert
Patent: US2012/46290 A1, 2012 ;
Location in patent: Page/Page column 28 ;
US 20120046290 A1
反应条件
aluminium trichloride in dichloromethane 18 h; Ambient temperature;
参考文献
Michaelides, Michael R.; Hong, Yufeng; DiDomenico Jr., Stanley; Bayburt, Erol K.; Asin, Karen E.; Britton, Donald R.; Lin, Chun Wel; Shiosaki, Kazumi
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1585 - 1599
反应条件
diethyl ether; hydrochloric ether; sodium Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
参考文献
Hartough; Conley
Journal of the American Chemical Society, 1947 , vol. 69, p. 3096
参考文献
Sy et al.
Journal of the Chemical Society, 1954 , p. 1975,1977
反应条件
alkaline aqueous potassium permanganate solution
参考文献
Messina; Brown
Journal of the American Chemical Society, 1952 , vol. 74, p. 920,922
反应条件
1.1: trichlorophosphate / 0 °C / Heating 1.2: 4 h / 55 - 75 °C 1.3: 3 h / 20 °C 2.1: sodium sulfide / N,N-dimethyl-formamide; water / 0.25 h / 20 °C 2.2: 1.5 h / 20 °C 2.3: 1 h 3.1: potassium hydroxide; water / methanol / 3 h / Reflux 3.2: pH 3 View Scheme
参考文献
Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Paulsen, Holger; Riedl, Bernd; Scott, William J.; Smith, Roger A.; Wood, Jill; Hatoum-Mokdad, Holia; Lee, Wendy; Redman, Aniko; Johnson, Jeffrey; Sibley, Robert
Patent: US2012/46290 A1, 2012 ;
US 20120046290 A1
反应条件
1.1: sodium sulfide / N,N-dimethyl-formamide; water / 0.25 h / 20 °C 1.2: 1.5 h / 20 °C 1.3: 1 h 2.1: potassium hydroxide; water / methanol / 3 h / Reflux 2.2: pH 3 View Scheme
参考文献
Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Paulsen, Holger; Riedl, Bernd; Scott, William J.; Smith, Roger A.; Wood, Jill; Hatoum-Mokdad, Holia; Lee, Wendy; Redman, Aniko; Johnson, Jeffrey; Sibley, Robert
Patent: US2012/46290 A1, 2012 ;
US 20120046290 A1
反应条件
Yield given. Multistep reaction;
参考文献
Garrigues, B.; Oussaid, B.; Hubert, C.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, # 1 p. 58 - 63
反应条件
sodium hydroxide; nickel
参考文献
Sy et al.
Journal of the Chemical Society, 1954 , p. 1975,1977
参考文献
Manfredini; Simoni; Caminiti; Vertuani; Invidiata; Moscato; Hatse; De Clercq; Balzarini
Medicinal Chemistry Research, 1998 , vol. 8, # 6 p. 291 - 304
