2-氯-4-甲基噻唑-5-磺酰氯合成路线 （共 4 条）
反应条件
thionyl chloride in chlorosulfonic acid; ice-water
参考文献
Bayer Aktiengesellschaft
Patent: US6500817 B1, 2002 ;
反应条件
thionyl chloride 48 h; Heating / reflux;
参考文献
Fischer, Rudiger; Kleymann, Gerald; Betz, Ulrich; Baumeister, Judith; Bender, Wolfgang; Eckenberg, Peter; Handke, Gabriele; Hendrix, Martin; Henninger, Kerstin; Jensen, Axel; Keldenich, Jorg; Schneider, Udo; Weber, Olaf
Patent: US2004/6076 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
ammonia in tetrahydrofuran; water T=-10°C; 2 h;
参考文献
ABBOTT LABORATORIES
Patent: US2010/184766 A1, 2010 ;
Location in patent: Page/Page column 56 ;
反应条件
triethylamine in dichloromethane
T=0°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/7041 A1, 2007 ;
Location in patent: Page/Page column 235 ;
WO 2007/007041 A1
