2-苯基-1H-吡咯并-2,3-c吡啶合成路线 （共 7 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 1,10-phenanthroline; carbon monoxide in acetonitrile T=120°C; P=4560.31 Torr; 24 h;
参考文献
Gorugantula, Sobha P.; Carrero-Martinez, Grissell M.; Dantale, Shubhada W.; Soederberg, Bjoern C.G.
Tetrahedron, 2010 , vol. 66, # 10 p. 1800 - 1805
反应条件
hydrogenchloride; water in tetrahydrofuran T=50°C; 2 h;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1452525 A1, 2004 ;
Location in patent: Page 21 ;
反应条件
sec.-butyllithium in tetrahydrofuran; cyclohexane T=-40°C; 0.5 h;
参考文献
Song, Jinhua J.; Tan, Zhulin; Gallou, Fabrice; Xu, Jinghua; Yee, Nathan K.; Senanayake, Chris H.
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6512 - 6514
反应条件
iron; acetic acid in ethanol Heating;
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1: Et3N; CuI / Pd(PPh3)2Cl2 / dimethylformamide / 15 h / 20 °C 2: 66 percent / aq. DBU / methanol / 12 h / 85 °C View Scheme
参考文献
Harcken, Christian; Ward, Yancey; Thomson, David; Riether, Doris
Synlett, 2005 , # 20 art. no. S08305ST, p. 3121 - 3125
反应条件
1: acetophenone With allyl(1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)palladium(IV) chloride; sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.0833333 h; Inert atmosphere; 2: 3-amino-4-bromopyridine in tetrahydrofuran T=20 - 100°C; 4 h; Inert atmosphere; regioselective reaction;
参考文献
Spergel, Steven H.; Okoro, Danielle R.; Pitts, William
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5316 - 5319
反应条件
1: 91 percent / DDQ / acetonitrile; H2O; acetic acid / 0 °C 2: 85 percent / iron; AcOH / ethanol / Heating View Scheme
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
