2-氯-3-甲基-5-溴吡啶合成路线 （共 5 条）
反应条件
trichlorophosphate in dichloromethane; N,N-dimethyl-formamide
参考文献
ABBOTT LABORATORIES
Patent: EP1428824 A1, 2004 ;
Location in patent: Page 49 ;
反应条件
1: 68.55 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 76 percent / aq. NaNO2, CuBr, HBr View Scheme
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
methylamine in water T=180°C; 4 h;
参考文献
Toyama Chemical Co., Ltd.
Patent: US6335447 B1, 2002 ;
Location in patent: Page column 26 ;
反应条件
1: With n-butyllithium in tetrahydrofuran
T=-78°C; 2 h;
2: With methanol; sodium tetrahydroborate in tetrahydrofuran; N,N-dimethyl-formamide
0.5 h;
参考文献
BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas
Patent: WO2014/28669 A1, 2014 ;
Location in patent: Paragraph 00304 ;
