5-溴-6-氯烟酸合成路线

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/70818 A1, 2007 ;
Location in patent: Page/Page column 103 ;
WO 2007/070818 A1

17282-03-02-氯-3-溴-5-甲基吡啶

29241-62-15-溴-6-氯烟酸

参考文献

Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Hebeisen, Paul; Nettekoven, Matthias; Sander, Ulrike Obst; Panousis, Constantinos G.; Roever, Stephan
Patent: US2008/85906 A1, 2008 ;
Location in patent: Page/Page column 16 ;

5006-66-66-羟基烟酸

29241-62-15-溴-6-氯烟酸

参考文献

Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896

29241-62-15-溴-6-氯烟酸+

18107-18-1三甲基硅烷化重氮甲烷

78686-77-85-溴-6-氯烟酸甲酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew
Patent: WO2010/100475 A1, 2010 ;
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WO 2010/100475 A1

29241-62-15-溴-6-氯烟酸

78686-77-85-溴-6-氯烟酸甲酯

参考文献

Setliff, Frank L.; Hule, W. Reeves
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 3 p. 332 - 333

67-56-1甲醇+

29241-62-15-溴-6-氯烟酸

78686-77-85-溴-6-氯烟酸甲酯

参考文献

Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896

186581-53-3重氮甲烷+

29241-62-15-溴-6-氯烟酸

78686-77-85-溴-6-氯烟酸甲酯

参考文献

Setliff, Frank L.; Hule, W. Reeves
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 3 p. 332 - 333

29241-62-15-溴-6-氯烟酸

1012792-55-06-氯-5-(4-氯苯基)-3-吡啶羧酸甲酯

参考文献

Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896

2516-33-8羟甲基环丙烷+

29241-62-15-溴-6-氯烟酸

912454-38-7

参考文献

Roever, Stephan; Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Guba, Wolfgang; Hebeisen, Paul; Mohr, Susanne; Nettekoven, Matthias; Obst, Ulrike; Richter, Wolfgang F.; Ullmer, Christoph; Waldmeier, Pius; Wright, Matthew B.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9874 - 9896

64-17-5乙醇+

29241-62-15-溴-6-氯烟酸

952063-30-85-溴-6-氯烟酸乙酯

参考文献

Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Hovland, Ragnar; Petersson, Annika U.; Ray, Asim; Zetterberg, Fredrik
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2877 - 2881