1,2-二碘-4,5-二硝基苯合成路线 （共 7 条）
反应条件
sulfuric acid; sulfur trioxide; iodine
参考文献
Zimcik, Petr; Miletin, Miroslav; Radilova, Hana; Novakova, Veronika; Kopecky, Kamil; Svec, Jaroslav; Rudolf, Emil
Photochemistry and Photobiology, 2010 , vol. 86, # 1 p. 168 - 175
反应条件
1: 66 percent / Fe; aq. HCl / ethanol / 0.75 h / Heating 2: 55 percent / 1-methyl-pyrrolidin-2-one / 3 h / 120 °C View Scheme
参考文献
Youngblood, W. Justin
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3345 - 3356
反应条件
in tetrahydrofuran T=20°C; Substitution; 4 h;
参考文献
Pak, Joshua J.; Weakley, Timothy J. R.; Haley, Michael M.
Journal of the American Chemical Society, 1999 , vol. 121, # 36 p. 8182 - 8192
反应条件
1.1: triethylamine; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 12 h / |Inert atmosphere; |Darkness
2.1: acetic acid; zinc / ethanol / 0.17 h
3.1: water; benzene / 12 h / |Darkness
4.1: potassium carbonate / methanol; tetrahydrofuran / 1 h
5.1: cyclohexa-1,4-diene / chlorobenzene / 24 h / 180 °C / |Inert atmosphere
5.2: 16 h / |Resolution of racemate
View Scheme
参考文献
Spence, John D.; Rios, Andro C.; Frost, Megan A.; McCutcheon, Claire M.; Cox, Christopher D.; Chavez, Sonia; Fernandez, Ramiro; Gherman, Benjamin F.
Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10329 - 10339
反应条件
1: triethylamine; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 12 h / |Inert atmosphere; |Darkness
2: acetic acid; zinc / ethanol / 0.17 h
3: water; benzene / 12 h / |Darkness
4: potassium carbonate / methanol; tetrahydrofuran / 1 h
5: cyclohexa-1,4-diene / chlorobenzene / 24 h / 180 °C / |Inert atmosphere
View Scheme
参考文献
Spence, John D.; Rios, Andro C.; Frost, Megan A.; McCutcheon, Claire M.; Cox, Christopher D.; Chavez, Sonia; Fernandez, Ramiro; Gherman, Benjamin F.
Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10329 - 10339
反应条件
hydrogenchloride; iron in ethanol
0.75 h; Heating;
参考文献
Youngblood, W. Justin; Lindsey, Jonathan S.
Patent: US2011/15388 A1, 2011 ;
Location in patent: Page/Page column 26 ;
反应条件
1: 66 percent / Fe; aq. HCl / ethanol / 0.75 h / Heating
2: 55 percent / 1-methyl-pyrrolidin-2-one / 3 h / 120 °C
3: FeCl3*6H2O; O2 / 1-methyl-pyrrolidin-2-one / 20 h / 120 °C
View Scheme
参考文献
Youngblood, W. Justin
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3345 - 3356
