4-氟-2,1,3-苯并恶二唑合成路线 （共 7 条）
反应条件
sodium azide in dimethyl sulfoxide T=23°C; 2.5 h; Inert atmosphere;
参考文献
Jung, Michael E.; Dong, Timothy A.; Cai, Xiaolu
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2533 - 2535
反应条件
1: 78 percent / HSO3Cl / CHCl3 / 1) 1 h, room temperature, 2) reflux, 2 h 2: 20 percent / 6percent aq. NH4OH View Scheme
参考文献
Toyo'oka, Toshimasa; Imai, Kazuhiro
Analytical Chemistry, 1984 , vol. 56, p. 2461 - 2464
反应条件
chlorosulfonic acid in chloroform 1) 1 h, room temperature, 2) reflux, 2 h;
参考文献
Toyo'oka, Toshimasa; Imai, Kazuhiro
Analytical Chemistry, 1984 , vol. 56, p. 2461 - 2464
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform
参考文献
Oread Laboratories, Inc.
Patent: US4769467 A1, 1988 ;
反应条件
1: sodium nitrate; sulfuric acid / water / 0.07 h / 0 °C / Inert atmosphere 2: sodium hydrogencarbonate / water; acetonitrile / 28 h / 23 °C / Darkness; Inert atmosphere View Scheme
参考文献
Jung, Michael E.; Dong, Timothy A.; Cai, Xiaolu
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2533 - 2535
反应条件
sodium nitrate; sulfuric acid in water T=0°C; 0.0666667 h; Inert atmosphere;
参考文献
Jung, Michael E.; Dong, Timothy A.; Cai, Xiaolu
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2533 - 2535
反应条件
1: 78 percent / HSO3Cl / CHCl3 / 1) 1 h, room temperature, 2) reflux, 2 h
2: 20 percent / 6percent aq. NH4OH
3: 0.08 h / 50 °C / 0.1 M borate buffer with EDTA (pH 8.0)
View Scheme
参考文献
Toyo'oka, Toshimasa; Imai, Kazuhiro
Analytical Chemistry, 1984 , vol. 56, p. 2461 - 2464
