4,5,6,7-四氢苯并噻唑-2-胺合成路线 （共 14 条）
参考文献
Basu; Das-Gupta
Journal of the Indian Chemical Society, 1941 , vol. 18, p. 167
Full Text Show Details
Erlenmeyer; Schoenauer
Helvetica Chimica Acta, Engi-Festband <1941> 172, 178
反应条件
1: With phosphoric acid; sodium nitrite
T=-8°C; 1 h;
2: With hypophosphorous ether
T=0°C; 3 h;
参考文献
Costanzo, Michael J.; Almond Jr., Harold R.; Hecker, Leonard R.; Schott, Mary R.; Yabut, Stephen C.; Zhang, Han-Cheng; Andrade-Gordon, Patricia; Corcoran, Thomas W.; Giardino, Edward C.; Kauffman, Jack A.; Lewis, Joan M.; De Garavilla, Lawrence; Haertlein, Barbara J.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1984 - 2008
反应条件
dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 8 h;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Patent: EP1500655 A1, 2005 ;
Location in patent: Page 9 ;
反应条件
in benzene
T=20°C; 48 h;
参考文献
Zhu, Xiaoxiang; Yu, Qian-sheng; Cutler, Roy G.; Culmsee, Carsten W.; Holloway, Harold W.; Lahiri, Debomoy K.; Mattson, Mark P.; Greig, Nigel H.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5090 - 5097
