10,11-二氢-10-羟基卡马西平合成路线 （共 14 条）
反应条件
chiralcel OD-H column in ethanol; hexane; isopropyl alcohol T=25°C; Resolution of racemate;
参考文献
De Jesus Antunes, Natalicia; Wichert-Ana, Lauro; Coelho, Eduardo Barbosa; Della Pasqua, Oscar; Alexandre Jr., Veriano; Takayanagui, Osvaldo Massaiti; Tozatto, Eduardo; Lanchote, Vera Lucia
Chirality, 2013 , vol. 25, # 12 p. 897 - 903
反应条件
1: Licarbazepine With pyridine in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2,5-dioxotetrahydrofuran-3,4-diyldiacetate in ethyl acetate T=30 - 35°C; 1 h; Overall yield = 77.08 percent; Overall yield = 0.7 g; Further stages;
参考文献
WO2013/8194 A2, ;
Page/Page column 13 ;
反应条件
1: pyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 2: sodium carbonate / 2-methyl tetrahydrofuran / 30 °C / pH 6.8 - 7.3 / Aqueous phosphate buffer; Enzymatic reaction 3: sodium hydroxide; water / ethanol; 2-methyl tetrahydrofuran View Scheme
反应条件
chiralcel OD-H column in ethanol; hexane; isopropyl alcohol T=25°C; Resolution of racemate;
参考文献
Chirality, , vol. 25, # 12 p. 897 - 903
