1: di-tert-butyl dicarbonate; (S)-2-phenylglycine 2: methyl iodide With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan
Patent: WO2009/51910 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
WO 2009/051910 A1
1: di-tert-butyl dicarbonate; (S)-2-phenylglycine 2: methyl iodide With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan
Patent: WO2009/51910 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
WO 2009/051910 A1
1: (S)-2-phenylglycine With N,N-dicyclohexylamine in acetone T=20°C; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in water; acetonitrile T=0 - 20°C; pH=8; 3: With potassium hydrogensulfate in water; acetonitrile pH=2 - 3;
参考文献
Nowshuddin, Shaik; Rao; Reddy, A. Ram
Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031
