4-C-[[(甲基磺酰基)氧基]甲基]-3-O-(苄基)-D-赤式-呋喃戊糖 1,2-二乙酸酯 5-甲烷磺酸酯合成路线 （共 1 条）
反应条件
1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / Heating
1.2: 88 percent / trimethylsilyl triflate / acetonitrile / 4 h / Heating
2.1: 94 percent / aq. NaOH / dioxane; H2O / 1 h / 20 °C
3.1: 86 percent / dimethylformamide / 5 h / 100 °C
4.1: 91 percent / aq. NaOH / tetrahydrofuran / 1 h
5.1: 83 percent / HCO2NH4 / Pd(OH)2/C / methanol / 0.17 h / Heating
View Scheme
参考文献
Koshkin; Fensholdt; Pfundheller; Lomholt
Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8504 - 8512
