1,4,7,10-四氮杂环十二烷合成路线 (共 64 条)
反应条件
triethylamine in ethanol 4 h; Heating;
参考文献
Maumela, Hulisani; Hancock, Robert D.; Carlton, Laurence; Reibenspies, Joseph H.; Wainwright, Kevin P.
Journal of the American Chemical Society, 1995 , vol. 117, # 25 p. 6698 - 6707
反应条件
triethylamine in ethanol 4 h; Heating;
参考文献
Amin, Shahid; Morrow, Janet R.; Lake, Charles H.; Churchill, Melvyn Rowen
Angewandte Chemie, 1994 , vol. 106, # 7 p. 824 - 826
反应条件
triethylamine in acetonitrile T=60°C; 6 h; SolventConcentrationReagent/catalystTimeTemperature; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 54, # 8 p. 918 - 920
反应条件
sodium hydrogencarbonate in acetonitrile T=20°C; 40 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7410 - 7413
反应条件
triethylamine in methanol; dichloromethane 12 - 16 h;
参考文献
WO2005/32599 A1, ;
Page/Page column 22-24; figure 12 ;
反应条件
triethylamine in chloroform T=24.84°C; 14 - 20 h; Product distribution / selectivity;
参考文献
WO2005/3105 A1, ;
Page/Page column 6 ;
反应条件
in chloroform T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 21 p. 5792 - 5795
反应条件
triethylamine in DMF (N,N-dimethyl-formamide) T=24.84°C; 14 - 20 h; Product distribution / selectivity;
参考文献
WO2005/3105 A1, ;
Page/Page column 6 ;
反应条件
potassium carbonate in chloroform T=24.84°C; 14 - 20 h; Product distribution / selectivity;
参考文献
WO2005/3105 A1, ;
Page/Page column 6 ;
反应条件
1: triethylamine / chloroform / 20 °C / Inert atmosphere 2: potassium carbonate / acetonitrile / 3 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 12 h / 20 °C View Scheme
参考文献
Heppeler; Froidevaux; Maecke; Jermann; Behe; Powell; Hennig
Chemistry - A European Journal, 1999 , vol. 5, # 7 p. 1974 - 1981