6-甲氧基-2-甲基苯并噻唑合成路线 （共 17 条）
反应条件
1: With copper(l) iodide; Na2S*9H2O in N,N-dimethyl-formamide T=80°C; 12 h; 2: With hydrogenchloride in N,N-dimethyl-formamide T=20°C;
参考文献
Ma, Dawei; Xue, Peng; Jiang, Yongwen; Xie, Siwei; Zhang, Xiaojing; Dong, Jinhua
Angewandte Chemie, International Edition, 2009 , vol. 48, # 23 p. 4222 - 4225
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6757 - 6767
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin; YANG, Heping; YU, Yajun
Patent: WO2013/91502 A1, 2013 ;
Location in patent: Page/Page column 28; 29 ;
反应条件
1-methyl-pyrrolidin-2-one; sodium hydride T=150°C; 1 h;
参考文献
Spitulnik,M.J.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 1073 - 1074
反应条件
disulfur dichloride T=50 - 70°C; Reduktion des Reaktionsprodukts mit Na2S2O4 in waessrig-alkoholischer Natronlauge bei 50grad und Behandlung mit Acetanhydrid in waessrig-alkoholischer Loesung;
参考文献
Koenig
Chemische Berichte, 1928 , vol. 61, p. 2070
反应条件
1: Br2 / acetic acid / Ambient temperature 2: aq. HCl / Heating View Scheme
参考文献
Barnikow,G.; Kunzek,H.
Journal fuer Praktische Chemie (Leipzig), 1965 , vol. 30, p. 13 - 17
反应条件
1: potassium hydroxide; water / 24 h / |Reflux 2: toluene / 80 °C View Scheme
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin; YANG, Heping; YU, Yajun
Patent: WO2013/91502 A1, 2013 ;
反应条件
in methanol Irradiation;
参考文献
Maki,Y.; Sako,M.
Tetrahedron Letters, 1976 , # 11 p. 851 - 854
反应条件
hydrogenchloride Heating;
参考文献
Barnikow,G.; Kunzek,H.
Journal fuer Praktische Chemie (Leipzig), 1965 , vol. 30, p. 13 - 17
反应条件
1: S2cl2 2: aqueous NaOH 3: zinc-powder View Scheme
参考文献
Takahashi et al.
Yakugaku Zasshi, 1951 , vol. 71, p. 41,43
Chem.Abstr., 1951 , p. 7109
