1,4-立方烷二甲酸二甲酯合成路线 （共 16 条）
反应条件
Dowex 50W-X8 resin in methanol 24 h; Reflux;
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
sulfuric acid 18 h; Inert atmosphereReflux;
参考文献
Falkiner, Michael J.; Littler, Stuart W.; McRae, Kenneth J.; Savage, G. Paul; Tsanaktsidis, John
Organic Process Research and Development, 2013 , vol. 17, # 12 p. 1503 - 1509
反应条件
1.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 2.1: sodium hydroxide / methanol / 3 h / |Reflux 3.1: sulfuric acid / 25 h / 20 - 25 °C 4.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 4.2: 1.5 h / |Reflux; |Inert atmosphere 4.3: 4.5 h / |Reflux; |Inert atmosphere 5.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
1.1: sodium hydroxide / methanol / 3 h / |Reflux 2.1: sulfuric acid / 25 h / 20 - 25 °C 3.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 3.2: 1.5 h / |Reflux; |Inert atmosphere 3.3: 4.5 h / |Reflux; |Inert atmosphere 4.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
1.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 1.2: 1.5 h / |Reflux; |Inert atmosphere 1.3: 4.5 h / |Reflux; |Inert atmosphere 2.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
1.1: Dowex 50W-X8 resin / toluene / 30 h / |Dean-Stark; |Heating 2.1: bromine / 1,4-dioxane / 60 h / 10 - 20 °C / |Inert atmosphere 3.1: sodium hydroxide / methanol / 3 h / |Reflux 4.1: sulfuric acid / 25 h / 20 - 25 °C 5.1: hydrogenchloride / methanol; water / 40 h / |Inert atmosphere; |Irradiation 5.2: 1.5 h / |Reflux; |Inert atmosphere 5.3: 4.5 h / |Reflux; |Inert atmosphere 6.1: Dowex 50W-X8 resin / methanol / 24 h / |Reflux View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830
反应条件
potassium hydroxide 1.) reflux, 3.5 h, 2.) MeOH, overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hasegawa, Takeshi; Nigo, Tomohiro; Kuwatani, Yoshiyuki; Ueda, Ikuo
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 9 p. 2676 - 2681
反应条件
T=20°C; 24 h; Yield given;
参考文献
Irngartinger, Hermann; Strack, Stefan; Gredel, Frank
Liebigs Annales, 1996 , # 3 p. 311 - 315
反应条件
in tetrahydrofuran; pentane T=-78°C; effect of substrates addition order; var. alkyllithium and aryllithium; other 4-haloiodocubanes; Product distributionMechanism;
参考文献
Eaton; Tsanaktsidis
Journal of the American Chemical Society, 1990 , vol. 112, # 2 p. 876 - 878
反应条件
sodium hydroxide in methanol; water 4 h; Heating;
参考文献
Griffiths, Justin R.; Tsanaktsidis, John; Savage, G. Paul; Priefer, Ronny
Thermochimica Acta, 2010 , vol. 499, # 1-2 p. 15 - 20
