1,4-立方烷二甲酸二甲酯合成路线 （共 16 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol Ambient temperature;
参考文献
Synthesis, , # 5 p. 501 - 502
反应条件
sodium hydroxide in tetrahydrofuran; methanol
参考文献
Al Hussainy, Rana; Verbeek, Joost; Van Der Born, Dion; Braker, Anton H.; Leysen, Josee E.; Knol, Remco J.; Booij, Jan; Herscheid
Journal of Medicinal Chemistry, 2011 , vol. 54, # 10 p. 3480 - 3491
反应条件
sodium hydroxide in tetrahydrofuran; methanol Ambient temperature;
参考文献
Synthesis, , # 5 p. 501 - 502
反应条件
1: 78 percent / HCl 2: 15 percent / LiCl, Pb(OAc)4 / CCl4 / 17 h / Heating View Scheme
参考文献
Irngartinger, Hermann; Strack, Stefan; Gredel, Frank
Liebigs Annales, 1996 , # 3 p. 311 - 315
反应条件
1: 89 percent / NaOH / methanol; tetrahydrofuran / Ambient temperature
2: N-Me-morpholine / tetrahydrofuran / -10 °C
3: NaBH4 / H2O / 3 h / Ambient temperature
View Scheme
参考文献
Harris, Benjamin; Savage, G. Paul; White, Jonathan M.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 19 p. 3151 - 3158
反应条件
1.1: 92 percent / NaOH / methanol; tetrahydrofuran
2.1: iodobenzene diacetate; I2 / benzene / 7 h / Heating
3.1: 4.76 g / aq. NaOH / methanol; tetrahydrofuran / 20 °C
4.1: BuLi / tetrahydrofuran; hexane / 0.08 h / -78 °C
4.2: 88 percent / MeOH / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Priefer, Ronny; Farrell, Patrick G.; Harpp, David N.
Synthesis, 2002 , # 18 p. 2671 - 2673
