6-氟-3,4-二氢-1H-2-萘酮合成路线 （共 9 条）
反应条件
thionyl chloride; aluminium trichloride in dichloromethane; 1,2-dichloro-ethane
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: US6140354 A1, 2000 ;
反应条件
thionyl chloride in ice-water; anhydrous dichloroethane; dichloromethane
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: EP1076644 B1, 2004 ;
Location in patent: Page 33-34; 36 ;
EP 1076644 B1
参考文献
Stjernlof; Ennis; Hansson; Hoffman; Ghazal; Sundell; Smith; Svensson; Carlsson; Wikstrom
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2202 - 2216
反应条件
aluminium chloride in dichloromethane; water
参考文献
Imperial Chemical Industries PLC
Patent: US4431834 A1, 1984 ;
反应条件
1: NBS 3: (hydrolysis) 4: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
1: (hydrolysis) 2: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
2: (hydrolysis) 3: SOCl2 View Scheme
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1970 , vol. 23, p. 1921 - 1937
反应条件
1: TiCl4 / CH2Cl2; tetrahydrofuran / 2 h / 0 °C 2: Ph3COH, TFA / 48 h / Ambient temperature View Scheme
参考文献
Ellingboe, John W.; Lombardo, Louis J.; Alessi, Thomas R.; Nguyen, Thomas T.; Guzzo, Frieda; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2485 - 2493
反应条件
diethylamino-sulfur trifluoride
参考文献
Adcock,W. et al.
Australian Journal of Chemistry, 1976 , vol. 29, p. 2571 - 2581
