3-氨基-5-氯-2-甲基苯甲酸甲酯合成路线 （共 3 条）
反应条件
stannous chloride dihydrate in ethyl acetate 3 h; Reflux;
参考文献
GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar
Patent: WO2013/173441 A2, 2013 ;
Location in patent: Page/Page column 108; 109 ;
反应条件
1.1: sulfuric acid / 0.17 h / -10 °C 1.2: 0.5 h / -10 °C 2.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C 3.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar
Patent: WO2013/173441 A2, 2013 ;
反应条件
1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C 2: water; ammonium chloride; iron / ethanol / 1 h / 80 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BURGESS, Joelle, Lorraine; DUQUENNE, Celine; KNIGHT, Steven, David; MILLER, William, Henry; NEWLANDER, Kenneth, Allen; VERMA, Sharad, Kumar
Patent: WO2013/173441 A2, 2013 ;
