2,4-二羟基-6-甲氧基嘧啶合成路线 （共 10 条）
反应条件
boron trifluoride diethyl etherate 2 h; Heating;
参考文献
Rudenko, E. S.; Krasnov, K. A.; Slesarev, V. I.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 12.2 p. 2337 - 2341
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 12 p. 2608 - 2613
反应条件
in tetrahydrofuran T=20°C; partial methylation, oth. solvent;
参考文献
Krasnov, K. A.; Slesareva, V. I.; Studentsov, E. P.; Slesarev, V. I.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 9 p. 1765 - 1769
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 9 p. 1995 - 2000
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Zakharov, A.P.; Grigor'eva, E. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 11 p. 1523 - 1526
反应条件
trichlorophosphate 4 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117051 A1, 2008 ;
Location in patent: Page/Page column 29 ;
WO 2008/117051 A1
反应条件
potassium carbonate in water T=5 - 10°C; 1.5 h;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Selimanova, I. N.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 7 p. 1215 - 1220
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 7 p. 1531 - 1537
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Zakharov, A.P.; Grigor'eva, E. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 11 p. 1523 - 1526
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Zakharov, A.P.; Grigor'eva, E. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 11 p. 1523 - 1526
反应条件
1: 50 percent / K2CO3 / H2O / 1.5 h / 5 - 10 °C
2: 83 percent / CH3ONa / dimethylsulfoxide / 0.02 h / 40 - 50 °C
View Scheme
参考文献
Krasnov, K. A.; Slesarev, V. I.; Selimanova, I. N.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 7 p. 1215 - 1220
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 7 p. 1531 - 1537
反应条件
lithium hydride
1.) DMSO, 50 deg C, 10 min, 2.) DMSO, 40 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Selimanova, I. N.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 7 p. 1215 - 1220
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 7 p. 1531 - 1537
反应条件
in methanol
T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Krasnov, K. A.; Slesarev, V. I.; Zakharov, A.P.; Grigor'eva, E. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 11 p. 1523 - 1526
