pyridinium chlorochromate in dichloromethane T=25°C; 13 h;

sodium hydride in tetrahydrofuran T=20°C; 26 h; Reflux;

1.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / 12 h / 125 °C 1.2: 2 h / 90 °C 2.1: pyridinium chlorochromate / dichloromethane / 13 h / 25 °C View Scheme

1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=10 - 50°C; Inert atmosphere; 2: bromobenzoic acid chloride in acetonitrile T=0 - 70°C; Inert atmosphere; 3: With hydrogenchloride in water; acetonitrile pH=5 - 6;

1.1: thionyl chloride / 2 h / |Reflux 2.1: triethylamine; magnesium chloride / acetonitrile / 10 - 50 °C / |Inert atmosphere 2.2: 0 - 70 °C / |Inert atmosphere 2.3: pH 5 - 6 View Scheme

hydrogenchloride in methanol; water T=70°C; 6 h;