2-巯基-5-甲基-1,3,4-噻二唑合成路线 （共 30 条）
反应条件
pyridine; hydrogenchloride; nitrogen in methanol; dichloromethane; 1-chloro-1,1-difluoro-methane; water
参考文献
Bristol-Myers Company
Patent: US4868294 A1, 1989 ;
反应条件
boron trifluoride in acetonitrile T=30°C; 1.5 h;
参考文献
Saikawa; Takano; Momonoi; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 12 p. 5534 - 5538
反应条件
pyridine; methanol 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min; Yield given. Multistep reaction;
参考文献
Walker, Donald G.; Brodfuehrer, Paul R.; Brundidge, Steven P.; Shih, Kun Mao; Sapino, Chester
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 983 - 991
反应条件
pyridine in acetone T=5 - 10°C; 2 h;
参考文献
Yazawa, Hisatoyo; Goto, Shunsuke
Tetrahedron Letters, 1985 , vol. 26, # 31 p. 3703 - 3706
反应条件
in argon matrix T=-263.16°C; 2.75 h; UV-irradiation;
参考文献
Rostkowska, Hanna; Lapinski, Leszek; Nowak, Maciej J.
Journal of Physical Organic Chemistry, 2010 , vol. 23, # 1 p. 56 - 66
反应条件
potassium hydroxide in ethanol 6 h; Heating;
参考文献
Zheng, Yan; Du, Miao; Li, Jian-Rong; Zhang, Ruo-Hua; Bu, Xian-He
Dalton Transactions, 2003 , # 8 p. 1509 - 1514
反应条件
triethylamine in dichloromethane Yields of byproduct given;
参考文献
Baczko, Krystyna; Plusquellec, Daniel
Tetrahedron, 1991 , vol. 47, # 23 p. 3817 - 3828
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Cook, Andrew G.; Wardell, James L.; Imrie, Corrie T.
Chemistry and Physics of Lipids, 2011 , vol. 164, # 2 p. 118 - 124
参考文献
Tetrahedron Letters, , vol. 38, # 26 p. 4693 - 4696
反应条件
in argon matrix T=-263.16°C; 2.75 h; UV-irradiation;
参考文献
Rostkowska, Hanna; Lapinski, Leszek; Nowak, Maciej J.
Journal of Physical Organic Chemistry, 2010 , vol. 23, # 1 p. 56 - 66
