1,4,8,11-四氮杂环十四烷合成路线 （共 60 条）
反应条件
potassium carbonate in acetonitrile T=55 - 60°C; 3.5 h;
参考文献
Li, Cong; Wong, Wing-Tak
Tetrahedron Letters, 2002 , vol. 43, # 17 p. 3217 - 3220
反应条件
1: Hexamethylphosphorigsaeretriamid / toluene / Heating 2: 2 N NaOH 3: Na2CO3 / dimethylformamide / 2 h / 100 °C 4: 3 N HCl / 10 h / Heating View Scheme
参考文献
Filali, Ayoub; Yaouanc, Jean-Jacques; Handel, Henri
Angewandte Chemie, 1991 , vol. 103, # 5 p. 563 - 564
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
Fabbrizzi, Luigi; Foti, Francesco; Licchelli, Maurizio; Maccarini, Paola M; Sacchi, Donatella; Zema, Michele
Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 21 p. 4965 - 4972
参考文献
Boitrel, Bernard; Andrioletti, Bruno; Lachkar, Mohammed; Guilard, Roger
Tetrahedron Letters, 1995 , vol. 36, # 28 p. 4995 - 4998
反应条件
in dichloromethane 4 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Dessolin, Jean; Galea, Pascale; Vlieghe, Patrick; Chermann, Jean-Claude; Kraus, Jean-Louis
Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 229 - 241
反应条件
1: acetonitrile; H2O 2: acetonitrile / Ambient temperature View Scheme
参考文献
Weisman, Gary R.; Wong, Edward H.; Hill, Daniel C.; Rogers, Mark E.; Reed, David P.; Calabrese, Joseph C.
Chemical Communications, 1996 , # 8 p. 947 - 948
反应条件
1: 1,4,8,11-tetraazacyclo-tetradecane With potassium carbonate in chloroform T=20°C; 2 h; 2: 1-iodo-propane in chloroform 24 h; Heating;
参考文献
Jeong, Jae Min; Hong, Sung Hyun; Kim, Young Joo; Lee, Dong Soo; Chung, June-Key; Cho, Jung-Hyuck; Lee, Myung Chul
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 4 p. 277 - 285
反应条件
1: 87 percent / Et3N / CH2Cl2 / 12 h 2: 82 percent / BH3*THF / tetrahydrofuran / Heating View Scheme
参考文献
Alcock; Benniston; Grant; Omar; Moore
Journal of the Chemical Society - Series Chemical Communications, 1991 , # 21 p. 1573 - 1575
反应条件
triethylamine in dichloromethane 12 h;
参考文献
Alcock; Benniston; Grant; Omar; Moore
Journal of the Chemical Society - Series Chemical Communications, 1991 , # 21 p. 1573 - 1575
反应条件
triethylamine in ethanol 20 h; Heating;
参考文献
Tsukube, Hiroshi; Adachi, Hayamitsu; Morosawa, Shiro
Journal of Organic Chemistry, 1991 , vol. 56, # 25 p. 7102 - 7108
