1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=10 - 30°C; 3.125 h; Inert atmosphereLarge scale reaction; 2: Large scale reaction;
参考文献
Weiberth, Franz J.; Hanna, Reda G.; Lee, George E.; Polverine, Yvonne; Klein, Joseph T.
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 704 - 709
1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=14 - 29°C; 2.86667 h; Inert atmosphere; 2: Large scale reaction;
参考文献
Weiberth, Franz J.; Hanna, Reda G.; Lee, George E.; Polverine, Yvonne; Klein, Joseph T.
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 704 - 709
1: 4-pyridinecarbonitrile With sulfuric acid in methanol; water T=20°C; 0.166667 h; 2: With iron(II) sulfate in methanol; water 2.33333 h; 3: hydroxylamine-o-sulphonic acid With sulfuric acid; iron(II) sulfate in methanol; water 3 h; Product distribution / selectivity;
参考文献
KUDOS PHARMACEUTICALS LIMITED
Patent: WO2006/21801 A1, 2006 ;
Location in patent: Page/Page column 65-66 ;
WO 2006/021801 A1
