2-(2’-吡啶)-苯胺合成路线 （共 22 条）
反应条件
sodium dithionite in ethanol; water
参考文献
McKinnon, David M.; Duncan, K.Ann; McKinnon, Aileen M.; Spevack, Perry A.
Canadian Journal of Chemistry, 1985 , vol. 63, p. 882 - 886
反应条件
1: 1-Bromo-2-aminobenzene With palladium diacetate; triethylamine; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane T=80°C; 1 h; 2: 2-bromo-pyridine With Ba(OH)2*8H2O in 1,4-dioxane; water T=100°C; 4 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Patent: WO2009/100014 A1, 2009 ;
Location in patent: Page/Page column 236-237 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Grohmann, Christoph; Wang, Honggen; Glorius, Frank
Organic Letters, 2013 , vol. 15, # 12 p. 3014 - 3017
反应条件
hydrazine hydrate in acetonitrile T=20°C; 1 h; Inert atmosphere;
参考文献
Yu, Songjie; Wan, Boshun; Li, Xingwei
Organic Letters, 2013 , vol. 15, # 14 p. 3706 - 3709
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethylene glycol dimethyl ether; water T=23 - 100°C;
参考文献
Lee, Eunsung; Hooker, Jacob M.; Ritter, Tobias
Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17456 - 17458
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C 2: copper(I) oxide; ammonium hydroxide / water; ethanol / 4 h / 25 - 45 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 11-12 p. 2211 - 2217
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Xie, Fang; Qi, Zisong; Li, Xingwei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 45 p. 11862 - 11866
Angew. Chem., 2013 , vol. 125, # 45 p. 12078 - 12082,5
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
反应条件
manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide T=60°C; 16 h;
参考文献
Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel
Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
反应条件
1: Et3N; [1,1'-biphenyl]-2-yldicyclohexylphosphine / Pd(OAc)2 / dioxane / 1 h / 80 °C 2: 85 mg / aq. Ba(OH)2 / dioxane / 4 h / 100 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 17 p. 3064 - 3068
