(4-羟基-2-疏基嘧啶-5-基)乙酸乙酯合成路线 （共 7 条）
反应条件
sodium; acetic acid; thiourea in ethanol
参考文献
ISIS Pharmaceuticals, Inc.; PepSeptive Biosystems, Inc.
Patent: US6441130 B1, 2002 ;
Title/Abstract Full Text Show Details
ISIS Pharmaceuticals, Inc.; Perseptive Biosystems, Inc.
Patent: US6451968 B1, 2002 ;
反应条件
Reaktion der Natrium-Verbindung;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 133 ;
参考文献
Johnson
Journal of the American Chemical Society, 1911 , vol. 33, p. 762
反应条件
1.1: sodium / diethyl ether / 17 h / 0 - 20 °C / Inert atmosphere 2.1: sodium ethanolate / ethanol / 17 h / 20 °C / Inert atmosphere; Reflux 2.2: 0 °C View Scheme
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
反应条件
hydrogenchloride; chloroacetic acid in water
参考文献
ISIS Pharmaceuticals, Inc.; PepSeptive Biosystems, Inc.
Patent: US6441130 B1, 2002 ;
Title/Abstract Full Text Show Details
ISIS Pharmaceuticals, Inc.; Perseptive Biosystems, Inc.
Patent: US6451968 B1, 2002 ;
反应条件
water; Raney nickel T=20°C; 90 h; Reflux;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 133 ;
反应条件
1: water / Raney nickel / 90 h / 20 °C / Reflux 2: trichlorophosphate / 0.08 h / Inert atmosphere; Reflux View Scheme
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
