6-氟-5-甲氧基-2,3-二氢-1H-茚-1-酮合成路线 （共 6 条）
反应条件
T=90°C; 0.166667 h; Microwave irradiation;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2007/71348 A1, 2007 ;
Location in patent: Page/Page column 78 ;
反应条件
methanesulfonic acid T=90°C; 0.166667 h;
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2011/159297 A1, 2011 ;
Location in patent: Page/Page column 87-88 ;
WO 2011/159297 A1
反应条件
accufluorTM in acetonitrile Fluorination; Heating; Title compound not separated from byproducts.;
参考文献
Stavber, Stojan; Jereb, Marjan; Zupan, Marko
Chemical Communications, 2000 , # 14 p. 1323 - 1324
反应条件
1.1: piperidine; pyridine / 13 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C 3.1: methanesulfonic acid / 0.17 h / 90 °C / Microwave irradiation; Sealed 3.2: pH 7 / Cooling with ice View Scheme
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2011/159297 A1, 2011 ;
WO 2011/159297 A1
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C 2.1: methanesulfonic acid / 0.17 h / 90 °C / Microwave irradiation; Sealed 2.2: pH 7 / Cooling with ice View Scheme
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2011/159297 A1, 2011 ;
WO 2011/159297 A1
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) T=70°C; 18 h; Ionic liquid;
参考文献
Pavlinac, Jasminka; Zupan, Marko; Stavber, Stojan
Molecules, 2009 , vol. 14, # 7 p. 2394 - 2409
