N,N-二甲基-1-[(2S)-2-吡咯烷基]甲胺合成路线 (共 2 条)
反应条件
1: L-prolinol With sulfuryl dichloride; triethylamine in dichloromethane T=-78 - 20°C; 20.1667 h; 2: dimethyl amine in tetrahydrofuran T=100°C; 14.5 h; 3: With sodium hydroxide; water; trifluoroacetic acid more than 3 stages;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1591443 A1, 2005 ;
Location in patent: Page/Page column 181-182 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Reflux;
参考文献
Diakos, Connie I.; Zhang, Mei; Beale, Philip J.; Fenton, Ronald R.; Hambley, Trevor W.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2807 - 2814