2-氟-5-硝基苯甲酸甲酯合成路线 （共 12 条）
反应条件
1: K2CO3 / dimethylsulfoxide / 2 h / 20 °C
2: iron; NH4Cl / tetrahydrofuran; methanol; H2O / 3 h / 100 °C
3: LiAlH4 / tetrahydrofuran / 7 h / 20 °C
View Scheme
参考文献
Hirashima, Shintaro; Oka, Takahiro; Ikegashira, Kazutaka; Noji, Satoru; Yamanaka, Hiroshi; Hara, Yoshinori; Goto, Hiroyuki; Mizojiri, Ryo; Niwa, Yasushi; Noguchi, Toru; Ando, Izuru; Ikeda, Satoru; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3181 - 3186
反应条件
potassium carbonate in dimethyl sulfoxide
T=80°C; 1 h;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2009/80836 A2, 2009 ;
Location in patent: Page/Page column 70 ;
