2-(4-氟苯基)丙二酸二乙酯合成路线 （共 5 条）
反应条件
1: ethyl 2-(4-fluorophenyl)acetate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1 h; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=20°C; 14 h; Further stages.;
参考文献
Bustos, Eduardo; Gotor-Fernandez, Vicente; Montejo-Bernardo, Jose; Garcia-Granda, Santiago; Gotor, Vicente
Organic Letters, 2007 , vol. 9, # 21 p. 4203 - 4206
反应条件
Cu; caesium carbonate in dimethyl sulfoxide T=70°C; Ullmann Condensation; 6 h; Inert atmosphere;
参考文献
Pai, Gita; Chattopadhyay, Asoke P.
Synthesis (Germany), 2013 , vol. 45, # 11 art. no. SS-2013-N0034-OP, p. 1475 - 1482
反应条件
tri-tert-butyl phosphine; sodium hydride; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=70°C; 3 h;
参考文献
Pai, Gita; Chattopadhyay, Asoke P.
Synthesis (Germany), 2013 , vol. 45, # 11 art. no. SS-2013-N0034-OP, p. 1475 - 1482
反应条件
1.1: 99 percent / 14 h / 20 °C 2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C 2.2: 80 percent / tetrahydrofuran / 14 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 21 p. 4203 - 4206
反应条件
1.1: (COCl)2; DMF / tetrahydrofuran / 0.17 h 2.1: LDA / tetrahydrofuran / 1 h / -78 °C 2.2: 65 percent / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 46 p. 13948 - 13949
