2,3-二氢-1,4-苯并二氧-5-甲醛合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=70°C; 16 h;
参考文献
Grudzien, Krzysztof; Malinska, Maura; Barbasiewicz, Michal
Organometallics, 2012 , vol. 31, # 9 p. 3636 - 3646
反应条件
manganese(IV) oxide in tetrahydrofuran T=20 - 60°C; 24 h;
参考文献
Allergan, Inc.
Patent: US2006/69144 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
US 20060069144 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide T=110°C; 2 h;
参考文献
Deveau, Amy Morin; Macdonald, Timothy L.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 803 - 807
反应条件
potassium fluoride in N-methyl-acetamide; water; ethylene dibromide
反应条件
lithium borohydride; Rink amine resin; water; trifluoroacetic acid; trimethyl orthoformate solid phase synthesis; 1) RT, 2) THF, 70 deg C, 5 h, 3) CH2Cl2, RT, 5 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Xie, Linghong; Zhang, Guifen; Griffith, Michael; Watson, Karen; Kiely, John S.
Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7011 - 7014
反应条件
1: With aminosulfonic acid in water; acetone T=0 - 5°C; 0.333333 h; 2: With sodium chlorite in water; acetone T=22 - 26°C; 18 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; DESHMUKH, Sanjay; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/153535 A1, 2013 ;
Location in patent: Page/Page column 63 ;
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol T=0 - 20°C;
参考文献
Deveau, Amy Morin; Macdonald, Timothy L.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 803 - 807
