3,5-二氟-4-羟基苯腈合成路线 （共 6 条）
反应条件
1-propanephosphonic acid cyclic anhydride in tetrahydrofuran; ethyl acetate T=20°C; Beckmann rearrangement; Inert atmosphere;
参考文献
Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; 2: With water in dichloromethane T=0°C;
参考文献
ASTRAZENECA AB
Patent: WO2006/135316 A1, 2006 ;
Location in patent: Page/Page column 55 ;
WO 2006/135316 A1
反应条件
hydroxylamine hydrochloride; 1-propanephosphonic acid cyclic anhydride; triethylamine in ethyl acetate; N,N-dimethyl-formamide T=100°C;
参考文献
Augustine, John Kallikat; Atta, Rajendra Nath; Ramappa, Balakrishna Kolathur; Boodappa, Chandrakantha
Synlett, 2009 , # 20 p. 3378 - 3382
反应条件
in N-methyl-acetamide; ethyl acetate
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h;
参考文献
Journal of Fluorine Chemistry, , vol. 102, # 1-2 p. 169 - 173
反应条件
hydrogenchloride; potassium cyanide; sodium nitrite 1.) 0 deg C, 2.) H2O, 50 deg C, 2 h; Yield givenMultistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 2 p. 329 - 332
