(R)-2-羟基-4-苯基丁酸合成路线 （共 58 条）
反应条件
1: Pseudomonas sp. lipase (Amano PS-C-II) / diisopropyl ether / 48 h / 25 °C 2: 85 percent / H2 / Pd/C / methanol / 0.17 h View Scheme
参考文献
Synlett, , # 12 art. no. G12405ST, p. 1936 - 1938
反应条件
1: mandelate racemase EC 5.1.2.2 / various solvent(s) / 24 h / 30 °C / pH 7.5 2: Pseudomonas sp. lipase (Amano PS-C-II) / diisopropyl ether / 48 h / 25 °C 3: 85 percent / H2 / Pd/C / methanol / 0.17 h View Scheme
参考文献
Synlett, , # 12 art. no. G12405ST, p. 1936 - 1938
反应条件
1: 61 percent / K2CO3 / methanol / 0 °C 2: 85 percent / H2 / Pd/C / methanol / 0.17 h View Scheme
参考文献
Synlett, , # 12 art. no. G12405ST, p. 1936 - 1938
反应条件
1: LiAlH4 / tetrahydrofuran 2: 75 percent / alkaline 3: hydrogen / 10percent Pd/C / acetic acid View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
1: 75 percent / alkaline 2: hydrogen / 10percent Pd/C / acetic acid View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
1: 90 percent / aluminum trichloride / 9 h / 5 °C 2: LiAlH4 / tetrahydrofuran 3: 75 percent / alkaline 4: hydrogen / 10percent Pd/C / acetic acid View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596
反应条件
hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 10 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Minamikawa, Hiroyuki; Hayakawa, Satoshi; Yamada, Tohru; Iwasawa, Nobuharu; Narasaka, Koichi
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 12 p. 4379 - 4384
反应条件
in various solvent(s) T=25°C; 30 h; lipase PS; Yield given. Title compound not separated from byproducts;
参考文献
Chadha; Manohar
Tetrahedron Asymmetry, 1995 , vol. 6, # 3 p. 651 - 652
反应条件
Pseudomonas sp. lipase Amano PS-C-II in di-isopropyl ether T=25°C; 48 h;
参考文献
Tetrahedron, , vol. 62, # 12 p. 2912 - 2916
