(R)-2-羟基-4-苯基丁酸合成路线 （共 58 条）
反应条件
1: 4A molecular sieves / chiral Zn catalyst / tetrahydrofuran / 24 h / -35 °C 2: NaNO2; CH3COOH / dimethylsulfoxide / 20 - 35 °C View Scheme
参考文献
Angewandte Chemie (International ed. in English), , vol. 41, # 5 p. 861 - 863
反应条件
acetic acid; sodium nitrite in dimethyl sulfoxide T=20 - 35°C; Title compound not separated from byproducts;
参考文献
Angewandte Chemie (International ed. in English), , vol. 41, # 5 p. 861 - 863
反应条件
1: 90 percent / NaOH / H2O / 20 - 70 °C 2: Lactobacillus sakei DSM 20017; BIS-TRIS buffer / H2O / 24 h / 42 °C / pH 6 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 10 p. 4028 - 4032
反应条件
in diethyl ether T=20 - 25°C; 30 h; lipase PS;
参考文献
Sugai, Takeshi; Ohta, Hiromichi
Agricultural and Biological Chemistry, 1991 , vol. 55, # 1 p. 293 - 294
反应条件
1: 45 percent / Novozyme 435 Candida antarctica lipase B; phosphate buffer / acetone / 24 h / 30 °C / pH 7.5 2: 74 percent / K2CO3 / methanol / 5 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 12 p. 2912 - 2916
反应条件
hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran P=20686.5 Torr; 5 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 2: 89 percent / NaNO2, 2N H2SO4, 4N H2SO4 / aq. acetic acid / 24 h, r.t.; 3 h, 100 deg C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 2: C52H50ClO4P2Ru(1+)*Cl(1-); hydrogen bromide; hydrogen / tetrahydrofuran; water / 12 h / Autoclave View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 2: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 3: C52H50ClO4P2Ru(1+)*Cl(1-); hydrogen bromide; hydrogen / tetrahydrofuran; water / 12 h / Autoclave View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
反应条件
1.1: magnesium / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: 1.5 h / -10 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 3.1: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 4.1: C52H50ClO4P2Ru(1+)*Cl(1-); hydrogen bromide; hydrogen / tetrahydrofuran; water / 12 h / Autoclave View Scheme
参考文献
Tetrahedron, , vol. 67, # 34 p. 6186 - 6190
