5-甲基吡啶-2-羧酸甲酯合成路线 （共 13 条）
反应条件
1: 2-methyl-5-methylpyridine With selenium(IV) oxide in pyridine Reflux; 2: methanol With sulfuric acid 5 h; Reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/81195 A1, 2009 ;
Location in patent: Page/Page column 84 ;
WO 2009/081195 A1
反应条件
triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium dihydroxide in methanol; N,N-dimethyl-formamide T=70°C; 20 h;
参考文献
EP1466902 A1, ;
Page 34 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine P=15201 Torr; Reflux;
参考文献
MERIAL LIMITED; MENG, Charles, Q.; MURRAY, Clare, Louise; BLUHN-CHERTUDI, Itta; SOUKRI, Mustapha
Patent: WO2013/3505 A1, 2013 ;
Location in patent: Page/Page column 57 ;
反应条件
N-chloro-succinimide; sodium methylate in tetrahydrofuran 16 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 63, # 22 p. 7840 - 7850
反应条件
1: SeO2 / pyridine / 26 h / Heating 2: 8.2 g / conc. H2SO4 / 8 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 34 p. 6951 - 6963
反应条件
sulfuric acid 8 h; Heating;
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 58, # 11 p. 2054 - 2056
反应条件
1 h; Irradiation; Product distributionMechanism;
参考文献
Sugiyama, Toru; Tobita, Estuo; Takagi, Kyoko; Sato, Michitsugu; Kumagai, Yasuyuki; et al.
Chemistry Letters, 1980 , p. 131 - 134
反应条件
N-bromosuccinmide; VAZO in tetrachloromethane 18 h; Heating / reflux;
参考文献
ANORMED INC.
Patent: WO2007/22371 A2, 2007 ;
Location in patent: Page/Page column 90 ;
WO 2007/022371 A2
反应条件
1: 2-bromo-4-methyl-pyridine With sodium hexamethyldisilazane in tetrahydrofuran
T=-30°C; 1 h;
2: 5-methylpicolic acid methyl ester in tetrahydrofuran
T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13134 A2, 2004 ;
Location in patent: Page 33 ;
WO 2004/013134 A2
