4-甲氧基吡啶-2-甲酸甲酯合成路线 （共 20 条）
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32667 A1, 2009 ;
Location in patent: Page/Page column 185 ;
WO 2009/032667 A1
反应条件
1: pyridine-2-carboxylic acid With thionyl chloride; sodium bromide T=90°C; 30 h; Inert atmosphere; 2: methanol T=0 - 70°C; Inert atmosphere;
参考文献
Donohoe, Timothy J.; Connolly, Matthew J.; Walton, Lesley
Organic Letters, 2009 , vol. 11, # 23 p. 5562 - 5565
反应条件
36 h; Heating; Yield given;
参考文献
Organic Preparations and Procedures International, , vol. 29, # 1 p. 117 - 122
反应条件
3 h; Heating / reflux;
参考文献
US7081461 B1, ;
Page/Page column 45 ;
US 7081461 B1
反应条件
phosphorus trichoride in chloroform 1.)r.t., 1 h 2.)45 deg C, 45 min; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 477 - 478
反应条件
1: 64 percent / HCl(g) / 1.)-10 deg C, 45 min 2.)reflux, 3 h 2: PCl3 / CHCl3 / 1.)r.t., 1 h 2.)45 deg C, 45 min View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 477 - 478
反应条件
1: thionyl chloride / sodium bromide / 24 h / Reflux 2: 24 h / 0 °C / Reflux View Scheme
反应条件
T=65°C; 36 h; Inert atmosphere;
参考文献
Donohoe, Timothy J.; Brian, Ptoton M.; Hargaden, Grainne C.; O'Riordan, Timothy J.C.
Tetrahedron, 2010 , vol. 66, # 33 p. 6411 - 6420
参考文献
Donohoe, Timothy J.; Johnson, Dale J.; Mace, Laura H.; Bamford, Mark J.; Ichihara, Osamu
Organic Letters, 2005 , vol. 7, # 3 p. 435 - 437
反应条件
1: 93 percent / NH2NH2 / methanol / 6 h / Heating 2: t-BuONO, TFAA / tetrahydrofuran / 0.5 h / 0 °C 3: toluene / 1.) reflux, 1 h, 2.) reflux, 10 h View Scheme
参考文献
Sundberg, Richard J.; Jiang, Songchun
Organic Preparations and Procedures International, 1997 , vol. 29, # 1 p. 117 - 122
