4-苄氧基-2-羟基苯乙酮合成路线 （共 34 条）
反应条件
1: With sodium T=160°C; 1 h; 2: With hydrogenchloride in water
参考文献
Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 723 - 739
反应条件
1: 1.8 g / Na / 48 h / Ambient temperature 2: 200 mg / HCOONa, CH3COOH / 10percent Pd/C / methanol / 5 h / Heating View Scheme
参考文献
Malhotra, S.; Sharma, V. K.; Parmar, V. S.
Journal of Chemical Research, Miniprint, 1988 , # 6 p. 1570 - 1582
反应条件
1: With copper(ll) bromide in chloroform; ethyl acetate Heating / reflux; 2: With sodium acetate in ethanol 1 h; Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/113529 A2, 2005 ;
Location in patent: Page/Page column 99-100 ;
反应条件
1: With potassium hydroxide in 1,4-dioxane; ethanol; water T=0 - 21°C; Algar-Flynn-Olyamada (AFO) Reaction; 66 h; 2: With sodium hydroxide; dihydrogen peroxide in 1,4-dioxane; ethanol; water T=0 - 21°C; Algar-Flynn-Olyamada (AFO) Reaction; 14 h;
参考文献
SINGAPORE POLYTECHNIC; SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
Patent: WO2007/75145 A1, 2007 ;
Location in patent: Page/Page column 34-35 ;
反应条件
1: 42 percent / 40 percent aq. KOH / dioxane; ethanol / 66 h / 20 °C 2: 41 percent / 5.4 percent aq. NaOH; 35 percent aq. H2O2 / dioxane; ethanol / 0 - 20 °C View Scheme
参考文献
Van Acker; Hageman; Haenen; Van der Vijgh; Bast; Menge
Journal of Medicinal Chemistry, 2000 , vol. 43, # 20 p. 3752 - 3760
反应条件
1: acetic acid; HNO3 2: HBr; acetic acid View Scheme
参考文献
Jadhav; Merchant
Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1951 , vol. 19/A, p. 35,36
Proceedings - Indian Academy of Sciences, Section A, 1951 , vol. 34, p. 152,154
反应条件
1: K2S2O8; aqueous KOH; pyridine / Erhitzen des Reaktionsprodukts mit wss.HCl und Na2SO3
2: K2CO3; acetone
3: concentrated HCl; acetic acid
View Scheme
参考文献
Laumas et al.
Proceedings - Indian Academy of Sciences, Section A, 1957 , vol. 46, p. 343,346
反应条件
in trifluoroacetic acid
70 h; Ambient temperature;
参考文献
Jain, A. C.; Arya, P.; Nayyar, N. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1030 - 1035
反应条件
1.1: triethylamine; acetic anhydride / o-xylene / 0.5 h / 20 °C
1.2: 50 h / 150 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -20 °C
2.2: 1.17 h / -20 - 0 °C
3.1: boron tribromide / dichloromethane / 7.33 h / 20 - 34 °C / |Inert atmosphere
4.1: ethanol / 18.17 h / 0 - 26 °C / |Inert atmosphere
5.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 1.08 h / -5 - 0 °C
5.2: 18.5 h / 20 °C
6.1: triethylamine / dichloromethane / 0.17 h / 20 °C
6.2: 21 h / 20 - 30 °C
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Youells, Scott; Beish, Sandra; Hu, Zhiyong; Branum, Shawn; Jain, Nareshkumar; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 731 - 738
反应条件
1.1: triethylamine; acetic anhydride / o-xylene / 0.5 h / 20 °C
1.2: 50 h / 150 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -20 °C
2.2: 1.17 h / -20 - 0 °C
3.1: boron tribromide / dichloromethane / 7.33 h / 20 - 34 °C / |Inert atmosphere
4.1: ethanol / 18.17 h / 0 - 26 °C / |Inert atmosphere
5.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 1.08 h / -5 - 0 °C
5.2: 18.5 h / 20 °C
6.1: triethylamine / dichloromethane / 0.17 h / 20 °C
6.2: 21 h / 20 - 30 °C
7.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -20 °C / |Inert atmosphere
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Youells, Scott; Beish, Sandra; Hu, Zhiyong; Branum, Shawn; Jain, Nareshkumar; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 731 - 738
