5-溴吡啶-2-羧酸甲酯合成路线 （共 27 条）
反应条件
in tetrahydrofuran T=0°C; 1 h; Inert atmosphereSealed tube;
参考文献
MERCK SHARP and DOHME CORP.; BRUBAKER, Jason; DINSMORE, Christopher J.; HOFFMAN, Dawn Marie; JUNG, Joon; LIU, Duan; PETERSON, Scott; SIU, Tony; TORRES, Luis E.; ZHANG, Hongjun; WEI, Zhongyong; SHI, Feng
Patent: WO2013/40863 A1, 2013 ;
Location in patent: Page/Page column 89-90 ;
WO 2013/040863 A1
反应条件
1: tert-butyl alcohol With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.166667 h; 2: 5-bromo-pyridine-2-carboxylic acid methyl ester in tetrahydrofuran; hexane T=0°C;
参考文献
Martin, Thibaut; Verrier, Cecile; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2008 , vol. 10, # 13 p. 2909 - 2912
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=20 - 90°C; Inert atmosphere;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2009/156966 A1, 2009 ;
Location in patent: Page/Page column 38-39 ;
WO 2009/156966 A1
反应条件
in tetrahydrofuran T=20°C;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng
Patent: WO2014/32498 A1, 2014 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: With sodium tetrahydroborate; ethanol T=0 - 20°C; 2: With hydrogenchloride in water 3: With potassium carbonate in water
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Bayer Pharma Aktiengesellschaft; KLAR, Jürgen; VOEHRINGER, Verena; TELSER, Joachim; LOBELL, Mario; SÜßMEIER, Frank; LI, Volkhart Min-Jian; BÖTTGER, Michael; GOLZ, Stefan; LANG, Dieter; SCHLEMMER, Karl-Heinz; SCHLANGE, Thomas; SCHALL, Andreas; FU, Wenlang
Patent: WO2013/4551 A1, 2013 ;
Location in patent: Page/Page column 35 ;
反应条件
1: 1-methyl-pyrrolidin-2-one / 1.5 h / 170 °C 2: sodium hydroxide / ethanol / 0.17 h / 20 °C View Scheme
参考文献
EISAI RandD MANAGEMENT CO., LTD.
Patent: US2012/190672 A1, 2012 ;
US 20120190672 A1
Title/Abstract Full Text Show Details
EISAI RandD MANAGEMENT CO., LTD.; HALL, Adrian; FARTHING, Christopher Neil; CASTRO PINEIRO, Jose, Luis
Patent: WO2012/98213 A1, 2012 ;
反应条件
toluene-4-sulfonic acid 24 h; Reflux;
参考文献
Martin, Thibaut; Laguerre, Claire; Hoarau, Christophe; Marsais, Francis
Organic Letters, 2009 , vol. 11, # 16 p. 3690 - 3693
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / 90 °C / Inert atmosphere 2: methanol; potassium hydroxide / 0 - 20 °C View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
反应条件
1: tetrahydrofuran / Reflux 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C View Scheme
参考文献
Voronkov, Andrew; Holsworth, Daniel D.; Waaler, Jo; Wilson, Steven R.; Ekblad, Bie; Perdreau-Dahl, Harmonie; Dinh, Huyen; Drewes, Gerard; Hopf, Carsten; Morth, Jens P.; Krauss, Stefan
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3012 - 3023
反应条件
potassium fluoride; C114H158O4P2Pd2; silver fluoride in 2-methyl tetrahydrofuran T=90°C; 14 h; Sealed tube;
参考文献
Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3792 - 3795
