1-溴-2-氯-4-硝基苯合成路线 （共 15 条）
反应条件
hydrogen bromide in acetonitrile T=60°C; 0.5 h;
参考文献
Synthesis, , # 14 p. 2180 - 2190
反应条件
ueber 2-Chlor-4-nitro-benzoldiazoniumperbromid;
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 22 I, p. 823
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 23 I, p. 283 Anm.
反应条件
1: alcohol; ammonia 2: ueber 2-Chlor-4-nitro-benzoldiazoniumperbromid View Scheme
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 22 I, p. 823
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 23 I, p. 283 Anm.
参考文献
American Chemical Journal, , vol. 22, p. 273
反应条件
1: SnCl2; aqueous HCl 2: sulfuric acid; nitrosylsulfuric acid; phosphoric acid / Eintragen der Reaktionsloesung in heisse wss. Schwefelsaeure 3: dimethyl sulfate; potassium carbonate; acetone View Scheme
参考文献
Faith et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 543,546
反应条件
1: potassium carbonate / tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 125 °C 2: zinc; acetic acid / tetrahydrofuran; methanol / 1 h / 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97684 A1, 2012 ;
WO 2012/097684 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in DMF (N,N-dimethyl-formamide) T=150°C; 0.25 h; Microwave;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/51890 A1, 2005 ;
Location in patent: Page/Page column 65-66 ;
反应条件
1: SnCl2; aqueous HCl 2: sulfuric acid; nitrosylsulfuric acid; phosphoric acid / Eintragen der Reaktionsloesung in heisse wss. Schwefelsaeure View Scheme
参考文献
Faith et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 543,546
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AUSTIN, Joel, Francis; SHARMA, Lisa, S.; BALOG, James, Aaron; HUANG, Audris; VELAPARTHI, Upender; DARNE, Chetan, Padmakar; SAULNIER, Mark, George
Patent: WO2012/15723 A1, 2012 ;
Location in patent: Page/Page column 108 ;
WO 2012/015723 A1
反应条件
caesium carbonate in toluene
T=100°C; Inert atmosphere;
参考文献
Steffen, Jamin D.; Coyle, Donna L.; Damodaran, Komath; Beroza, Paul; Jacobson, Myron K.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5403 - 5413
