2-(1H-吡咯-1-基)-1-乙胺合成路线 （共 17 条）
反应条件
1: pyridine / 60 °C 2: POCl3 View Scheme
参考文献
Castellote, Isabel; Vaquero, Juan J.; Fernandez-Gadea, Javier; Alvarez-Builla, Julio
Journal of Organic Chemistry, 2004 , vol. 69, # 25 p. 8668 - 8675
反应条件
trifluoroacetic acid in ethanol T=20 - 50°C; 12.25 h; Inert atmosphere;
参考文献
JIANGSU HANSOH PHARMACEUTICAL CO., LTD.; Tang, Peng Cho; Li, Xin; Li, Xiangqin; Chen, Yang; Wang, Bin; Zhu, Zhe
Patent: US2013/131068 A1, 2013 ;
Location in patent: Paragraph 0105 ;
反应条件
1: With acetic acid T=20°C; 48 h; 2: With water; sodium carbonate
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/90055 A1, 2009 ;
Location in patent: Page/Page column 105 ;
WO 2009/090055 A1
反应条件
1: 2-(1H-pyrrol-1-yl)ethanamine; formaldehyd With trifluoroacetic acid in ethanol; water T=25 - 50°C; 4.25 h; 2: With sodium hydrogencarbonate in water; ethyl acetate 3: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 25°C;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/90055 A1, 2009 ;
Location in patent: Page/Page column 123; 124 ;
WO 2009/090055 A1
反应条件
15 h; Heating; Yield given;
参考文献
De Pablo; Gandasegui; Vaquero; Garcia Navio; Alvarez-Builla
Tetrahedron, 1992 , vol. 48, # 40 p. 8793 - 8800
反应条件
in acetic acid
48 h; Ambient temperature;
参考文献
Jirkovsky, Ivo; Baudy, Reinhardt
Synthesis, 1981 , # 6 p. 481 - 483
反应条件
1: With 1,2,3-Benzotriazole; toluene-4-sulfonic acid in toluene
2: With sodium hydroxide in water; ethyl acetate
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/90055 A1, 2009 ;
Location in patent: Page/Page column 105; 106 ;
WO 2009/090055 A1
