2,4-二氯-5-嘧啶甲酰氯合成路线 （共 9 条）
反应条件
phosphorus pentachloride; trichlorophosphate T=0°C; 16 h; Inert atmosphereReflux;
参考文献
SANOFI-AVENTIS
Patent: US2011/251194 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
phosphorus pentachloride; trichlorophosphate T=115°C; 5 h;
参考文献
Schering AG
Patent: US2004/209895 A1, 2004 ;
Location in patent: Page column 19-20 ;
反应条件
phosphorus pentachloride; trichlorophosphate T=115°C; 6 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2006/34872 A1, 2006 ;
Location in patent: Page/Page column 51 ;
WO 2006/034872 A1
反应条件
water in diethyl ether T=35°C; 1 h;
参考文献
SANOFI
Patent: US2012/277220 A1, 2012 ;
Location in patent: Page/Page column 16 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 1 h;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; WANG, Xiaodong; ZHANG, Weihe; KIREEV, Dmitri; LIU, Jing; MCIVER, Andrew Louis
Patent: WO2014/85225 A1, 2014 ;
Location in patent: Page/Page column 18; 19; 28; 29 ;
反应条件
in tetrahydrofuran T=20°C; 0.166667 h;
参考文献
SANOFI-AVENTIS
Patent: US2011/251194 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
ammonium hydroxide in dichloromethane; water T=-20 - -15°C; Product distribution / selectivity;
参考文献
Singh, Rajinder; Tso, Kin; Zhang, Jing; Duncton, Matthew; Alvarez, Salvador; Kolluri, Rao; Ramphal, John; Holland, Sacha
Patent: US2011/130415 A1, 2011 ;
Location in patent: Page/Page column 41 ;
反应条件
Amberlyst A-21 ion exchange resin in ethyl acetate
T=20 - 50°C;
参考文献
AMGEN INC.
Patent: WO2007/24680 A1, 2007 ;
Location in patent: Page/Page column 42 ;
WO 2007/024680 A1
反应条件
Amberlyst A-21 ion exchange resin in ethyl acetate
T=60°C;
参考文献
AMGEN INC.
Patent: WO2005/9443 A1, 2005 ;
Location in patent: Page/Page column 76-77 ;
