(alphaR)-(9CI)-α-氨基-α-甲基-苯乙酸合成路线 （共 31 条）
参考文献
McKenzie; Clough
Journal of the Chemical Society, 1912 , vol. 101, p. 393
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
Catalytic hydrogenation; 10 h; atmospheric pressure;
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
10 Pd/C; hydrogen in ethanol
T=20°C; optical yield given as percent ee;
参考文献
Green, Jonathan E.; Bender, David M.; Jackson, Stona; O'donnell, Martin J.; Mccarthy, James R.
Organic Letters, 2009 , vol. 11, # 4 p. 807 - 810
反应条件
amidase-containing Rhodococcus sp. AJ270; nitrile hydratase in phosphate buffer
T=30°C; pH=7.0; 25 h;
参考文献
Wang, Mei-Xiang; Lin, Shuan-Jun; Liu, Jun; Zheng, Qi-Yu
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 4 p. 439 - 445
反应条件
T=37°C; Mycobacterium neoaurum ATCC 25795, pH 8-8.5; Yield given. Title compound not separated from byproducts;
参考文献
Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis
Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol; water
Catalytic hydrogenation;
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: 97 percent / C36H52N4O5 / toluene / 24 h / -75 °C
2: 97 percent / Ac2O
3: 95 percent / conc. HCl / 105 °C
4: H2; aq. HCl / Pd-C / methanol; H2O
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: 77 percent / 3 Angstroem molecular sieves / CH2Cl2 / 20 °C
2: 77 percent / polystyrene bead C36H52N4O5 / toluene / 6 h / -40 °C
3: 98 percent / 0.17 h
4: 95 percent / aq. HCl / 3 h / 105 °C
5: 100 percent / H2; aq. HCl / Pd-C / methanol / 10 h / atmospheric pressure
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: 77 percent / polystyrene bead C36H52N4O5 / toluene / 6 h / -40 °C
2: 98 percent / 0.17 h
3: 95 percent / aq. HCl / 3 h / 105 °C
4: 100 percent / H2; aq. HCl / Pd-C / methanol / 10 h / atmospheric pressure
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: 95 percent / conc. HCl / 105 °C
2: H2; aq. HCl / Pd-C / methanol; H2O
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
