(alphaR)-(9CI)-α-氨基-α-甲基-苯乙酸合成路线 （共 31 条）
反应条件
1: 98 percent / 0.17 h
2: 95 percent / aq. HCl / 3 h / 105 °C
3: 100 percent / H2; aq. HCl / Pd-C / methanol / 10 h / atmospheric pressure
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: 95 percent / aq. HCl / 3 h / 105 °C
2: 100 percent / H2; aq. HCl / Pd-C / methanol / 10 h / atmospheric pressure
View Scheme
参考文献
Vachal; Jacobsen
Organic letters, 2000 , vol. 2, # 6 p. 867 - 870
反应条件
1: With hydrogenchloride
48 h; Heating;
2: With methyloxirane in ethanol
T=60°C; 0.5 h;
参考文献
Baumann, Thomas; Vogt, Henning; Braese, Stefan
European Journal of Organic Chemistry, 2007 , # 2 p. 266 - 282
反应条件
1: Et3N / tetrahydrofuran / 2 h / 20 °C
2: 50 percent aq. NaOH; cetyltrimethylammonium chloride / 18 h / 80 °C
3: aq. conc. HCl / methanol / 2 h / 20 °C
4: K2CO3 / methanol / 0.17 h / 20 °C
5: 79 percent / tetrahydrofuran / 12 h / 20 °C
6: 79 percent / NaN3 / 15-crown-5 / tetrahydrofuran / 12 h / 20 °C
7: Jones' reagent / acetone / 0.25 h / 0 °C
8: H2 / Pd/C / ethanol / 16 h / 20 °C
View Scheme
参考文献
Masaki, Yukio; Arasaki, Hideki; Iwata, Masashi
Chemistry Letters, 2003 , vol. 32, # 1 p. 4 - 5
反应条件
1: 50 percent aq. NaOH; cetyltrimethylammonium chloride / 18 h / 80 °C
2: aq. conc. HCl / methanol / 2 h / 20 °C
3: K2CO3 / methanol / 0.17 h / 20 °C
4: 79 percent / tetrahydrofuran / 12 h / 20 °C
5: 79 percent / NaN3 / 15-crown-5 / tetrahydrofuran / 12 h / 20 °C
6: Jones' reagent / acetone / 0.25 h / 0 °C
7: H2 / Pd/C / ethanol / 16 h / 20 °C
View Scheme
参考文献
Masaki, Yukio; Arasaki, Hideki; Iwata, Masashi
Chemistry Letters, 2003 , vol. 32, # 1 p. 4 - 5
反应条件
1: K2CO3 / methanol / 0.17 h / 20 °C
2: 79 percent / tetrahydrofuran / 12 h / 20 °C
3: 79 percent / NaN3 / 15-crown-5 / tetrahydrofuran / 12 h / 20 °C
4: Jones' reagent / acetone / 0.25 h / 0 °C
5: H2 / Pd/C / ethanol / 16 h / 20 °C
View Scheme
参考文献
Masaki, Yukio; Arasaki, Hideki; Iwata, Masashi
Chemistry Letters, 2003 , vol. 32, # 1 p. 4 - 5
反应条件
1: 79 percent / NaN3 / 15-crown-5 / tetrahydrofuran / 12 h / 20 °C
2: Jones' reagent / acetone / 0.25 h / 0 °C
3: H2 / Pd/C / ethanol / 16 h / 20 °C
View Scheme
参考文献
Masaki, Yukio; Arasaki, Hideki; Iwata, Masashi
Chemistry Letters, 2003 , vol. 32, # 1 p. 4 - 5
反应条件
1: Jones' reagent / acetone / 0.25 h / 0 °C
2: H2 / Pd/C / ethanol / 16 h / 20 °C
View Scheme
参考文献
Masaki, Yukio; Arasaki, Hideki; Iwata, Masashi
Chemistry Letters, 2003 , vol. 32, # 1 p. 4 - 5
反应条件
hydrogenchloride
T=70°C;
参考文献
Chaari, M.; Jenhi, A.; Lavergne, J.-P.; Viallefont, Ph.
Journal of Organometallic Chemistry, 1991 , vol. 401, # 1.2 p. C10 - C13
反应条件
1.1: NaClO2; NaH2PO4; H2O2 / acetonitrile; H2O / 12 h
2.1: toluene; methanol / 0.08 h / 0 °C
3.1: pyridine / 15 h / 40 °C
3.2: trifluoroacetic anhydride / 48 h / 20 °C
3.3: SmI2 / tetrahydrofuran; methanol / 0.5 h / 20 °C
4.1: aq. HCl / 48 h / Heating
4.2: propylene oxide / ethanol / 0.5 h / 60 °C
View Scheme
参考文献
Baumann, Thomas; Vogt, Henning; Braese, Stefan
European Journal of Organic Chemistry, 2007 , # 2 p. 266 - 282
