(alphaR)-(9CI)-α-氨基-α-甲基-苯乙酸合成路线 （共 31 条）
反应条件
Rhodococcus sp. AJ270 cells in phosphate buffer
T=30°C; pH=7.0; 17.5 h; Title compound not separated from byproducts;
参考文献
Wang, Mei-Xiang; Liu, Jun; Wang, De-Xian; Zheng, Qi-Yu
Tetrahedron Asymmetry, 2005 , vol. 16, # 14 p. 2409 - 2416
反应条件
1.1: triethylamine / dichloromethane; hexane / 0.17 h / -45 °C / |Inert atmosphere
1.2: 17.3 h / -45 - 20 °C / |Inert atmosphere
2.1: 1-[3,5-bis(trifluoromethyl)phenyl]-3-{(2S)-3,3-dimethyl-1-[(triphenylphosphoranylidene)amino]butan-2-yl}thiourea / 96 h / -15 °C
3.1: potassium permanganate; potassium hydroxide; potassium dihydrogenphosphate / tert-butyl alcohol / 3.08 h / 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Nunez, Marta G.; Farley, Alistair J. M.; Dixon, Darren J.
Journal of the American Chemical Society, 2013 , vol. 135, # 44 p. 16348 - 16351
反应条件
1: C43H30F12N3PS / 24 h / 20 °C
2: potassium permanganate; potassium hydroxide; potassium dihydrogenphosphate / tert-butyl alcohol / 3.08 h / 20 °C
3: hydrogenchloride / water; tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
Nunez, Marta G.; Farley, Alistair J. M.; Dixon, Darren J.
Journal of the American Chemical Society, 2013 , vol. 135, # 44 p. 16348 - 16351
反应条件
1: 44.6 percent / NaI, Zn / dimethylformamide / 10 h / 120 °C
2: 4 N HCl / 5 h / Heating
View Scheme
参考文献
Olma
Polish Journal of Chemistry, 1996 , vol. 70, # 11 p. 1442 - 1447
反应条件
2: 65 percent / pyridine / 72 h / 0 °C
3: 44.6 percent / NaI, Zn / dimethylformamide / 10 h / 120 °C
4: 4 N HCl / 5 h / Heating
View Scheme
参考文献
Olma
Polish Journal of Chemistry, 1996 , vol. 70, # 11 p. 1442 - 1447
反应条件
1: 65 percent / pyridine / 72 h / 0 °C
2: 44.6 percent / NaI, Zn / dimethylformamide / 10 h / 120 °C
3: 4 N HCl / 5 h / Heating
View Scheme
参考文献
Olma
Polish Journal of Chemistry, 1996 , vol. 70, # 11 p. 1442 - 1447
反应条件
1: H2O / 72 h / 37 °C / aminopeptidase from Mycobacterium neoaurum ATCC 25795
2: 6 N HCl / 72 h / 90 °C
View Scheme
参考文献
Kruizinga, Wim H.; Bolster, John; Kellogg, Richard M.; Kamphuis, Johan; Boesten, Wilhelmus H. J.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 8 p. 1826 - 1827
反应条件
1.1: pyridine / 15 h / 40 °C
1.2: trifluoroacetic anhydride / 48 h / 20 °C
1.3: SmI2 / tetrahydrofuran; methanol / 0.5 h / 20 °C
2.1: aq. HCl / 48 h / Heating
2.2: propylene oxide / ethanol / 0.5 h / 60 °C
View Scheme
参考文献
Baumann, Thomas; Vogt, Henning; Braese, Stefan
European Journal of Organic Chemistry, 2007 , # 2 p. 266 - 282
反应条件
hydrogenchloride; silica gel; iron(III) chloride
Heating;
参考文献
Chaari, M.; Jenhi, A.; Lavergne, J.-P.; Viallefont, Ph.
Journal of Organometallic Chemistry, 1991 , vol. 401, # 1.2 p. C10 - C13
反应条件
hydrogenchloride
5 h; Heating;
参考文献
Olma
Polish Journal of Chemistry, 1996 , vol. 70, # 11 p. 1442 - 1447
