1: 60 percent / pyridine / Ambient temperature 2: thionyl chloride / diethyl ether / 4 h / Ambient temperature 3: 94 percent / triethylamine / diethyl ether / 5 h / 40 °C 4: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium(0) / 1.) THF, 45 deg C, 10 min; room temperature,30 min, 2.) reflux, 4 h 5: 82.5 percent / hexamethylphosphoric acid triamide / 11 h / 90 °C 6: 89 percent / disodium hydrogen phosphate, 6percent sodium amalgam / ethanol; tetrahydrofuran / 2.5 h / -20 °C 7: 99 percent / hydrogen / 5percent palladium on barium carbonate / 3 h / 1520 Torr / Ambient temperature View Scheme

1: 60 percent / pyridine / Ambient temperature 2: thionyl chloride / diethyl ether / 4 h / Ambient temperature 3: 84 percent / pyridine / CH2Cl2 / 2 h / Heating 4: 1.) sodium hydride / 2.) tetrakis(triphenylphosphine)palladium(0) / 1.) THF, room temperature, 30 min, 2.) reflux, 2.5 h 5: 76 percent / tetramethylammonium acetate / hexamethylphosphoric acid triamide / 6 h / 90 - 95 °C 6: disodium hydrogen phosphate, 6percent sodium amalgam / tetrahydrofuran; ethanol / 2.5 h / -20 °C 7: 98 percent / hydrogen / 5percent palladium on barium carbonate / ethanol / 2 h / 1520 Torr / Ambient temperature View Scheme