3-三甲基甲硅烷基丙炔醛合成路线 （共 23 条）
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4845210 A1, 1989 ;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 36, # 8 p. 1730 - 1731
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 8 p. 1866 - 1868
反应条件
1: 5-bromo-1-pentene With magnesium in diethyl ether 2: 3-(trimethylsilyl)-2-propynal in diethyl ether T=-78 - 20°C;
参考文献
Young, David G. J.; Burlison, Joseph A.; Peters, Ulf
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3494 - 3497
反应条件
in diethyl ether 0.166667 h; Ambient temperature;
参考文献
Meyer, Christophe; Marek, Ilane; Courtemanche, Gilles; Normant, Jean-F.
Journal of Organic Chemistry, 1995 , vol. 60, # 4 p. 863 - 871
反应条件
1.1: magnesium / diethyl ether 1.2: 87 percent / diethyl ether / -78 - 20 °C 2.1: 80 percent / imidazole / CH2Cl2 / 14 h / 20 °C View Scheme
参考文献
Young, David G. J.; Burlison, Joseph A.; Peters, Ulf
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3494 - 3497
反应条件
1: 81 percent / p-toluenesulfonic acid / benzene / Heating
2: 1.) BuLi / 1.) THF, -65 deg C, 30 min; 2.) THF, overnight, -65 deg C to 25 deg C
3: 86 percent / H2SO4 / acetone; H2O / 5 h / Heating
View Scheme
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
Ambient temperature;
参考文献
Suvorova, I. V.; Stadnichuk, M. D.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 2 p. 453 - 455,397 - 398
反应条件
Ambient temperature;
参考文献
Suvorova, I. V.; Stadnichuk, M. D.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 2 p. 453 - 455,397 - 398
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
1: 81 percent / p-toluenesulfonic acid / benzene / Heating
2: 1.) BuLi / 1.) THF, -65 deg C, 30 min; 2.) THF, overnight, -65 deg C to 25 deg C
3: 67 percent / H2SO4 / acetone; H2O / 5 h / Heating
View Scheme
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
