顺式-4-环戊烯-1,3-二醇合成路线 （共 46 条）
反应条件
T=50°C; acrylic supported Candida antarctica lipase B;
参考文献
Journal of the American Chemical Society, , vol. 115, # 23 p. 11014 - 11015
反应条件
in pyridine 72 h; Ambient temperatureporcine pancreatic lipase;
参考文献
Gazzetta Chimica Italiana, , vol. 118, # 12 p. 863 - 864
参考文献
Tetrahedron Letters, , vol. 29, # 51 p. 6769 - 6772
反应条件
in various solvent(s) T=50°C; 72 h; Candida antarctica lipase B (Novo SP-435); other meso-diols; enzymatic asymmetrization of meso-2-cycloalken-1,4-diols in organic media;
参考文献
Tetrahedron Letters, , vol. 33, # 48 p. 7287 - 7290
参考文献
Zeitschrift fuer Chemie (Stuttgart, Germany), , vol. 28, # 7 p. 264
反应条件
1: 56 percent / pyridine / Ambient temperature 2: 94 percent / TsOH / tetrahydrofuran; CH2Cl2 / 2 h / Ambient temperature 3: 96 percent / Ba(OH)2*8H2O / methanol / 1.5 h / Heating 4: 81 percent / Jones reagent / acetone / 0.5 h 5: 73 percent / aq.acetic acid / 15 h / Ambient temperature View Scheme
参考文献
Nara, M; Terashima, S.; Yamada, S.
Tetrahedron, 1980 , vol. 36, p. 3161 - 3170
反应条件
1.1: Lipase PS 'amano’ IM / hexadeuterioacetone / 48 h / 25 °C / |Inert atmosphere 2.1: 1,1,1-triethoxyethane; hydroquinone / water / 36.75 h / 25 - 144 °C 3.1: sulfuric acid / 41 h / 29 - 79 °C 4.1: methanol / 25 - 65 °C 5.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 35 - 65 °C / |Inert atmosphere; |Molecular sieve 6.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.17 h / 27 °C / |Inert atmosphere 6.2: 35 - 40 °C / |Inert atmosphere View Scheme
参考文献
Jackson, Mark; Dahanukar, Vilas Hareshwar; Joseph, Suju Chuttippari; Eda, Vishnu Vardhana Verma Reddy; Ramdas, Sandip Khobare
Patent: US2013/184476 A1, 2013 ;
反应条件
in camphor-10-sulfonic acid
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: EP751137 A1, 1997 ;
反应条件
(-)-10-CSA in toluene T=70°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Novak, Lajos; Kovacs, Peter; Pirok, Gyoergy; Kolonits, Pal; Hanania, Michel; Donath, Katalin; Szantay, Csaba
Tetrahedron, 1997 , vol. 53, # 28 p. 9789 - 9798
反应条件
1: 17 percent / pyridine / Ambient temperature 2: TsOH / tetrahydrofuran; CH2Cl2 / Ambient temperature 3: NaOH / tetrahydrofuran; H2O / 5 h / Ambient temperature 4: 1.) pyridine, 2.) aq.AcOH / 1.) CH2CH2, reflux, 15 h, 2.) pyridine, r.t., overnight 5: 1.) hydroquinone, 2.) KOH, 3.) TsOH / 1.) 140 deg C, 36 h, 2.) aq.MeOH, r.t., overnight, 3.) THF, r.t., overnight View Scheme
参考文献
Nara, M; Terashima, S.; Yamada, S.
Tetrahedron, 1980 , vol. 36, p. 3161 - 3170
