反应条件
1.1: Tebbe's reagent / toluene / 0.5 h / 0 - 20 °C 2.1: Dess-Martin periodane / dichloromethane / 0.5 h 3.1: cerium(III) chloride / tetrahydrofuran / 0.5 h / 0 °C 3.2: 1 h / 0 °C 4.1: borane-THF / tetrahydrofuran / 6 h / 0 - 20 °C 4.2: 0.5 h 5.1: N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 20 °C 6.1: Dess-Martin periodane / dichloromethane / 0.5 h 7.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 40 °C 7.2: 0.03 h / -78 °C 8.1: 2,6-dimethylpyridine / dichloromethane / 6 h / 0 °C 9.1: dichloro-acetic acid / dichloromethane / 2 h / 20 °C 10.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C 11.1: sodium chlorite; sodium dihydrogenphosphate; 1,1,2,2-tetramethylethylene / tetrahydrofuran; water; tert-butyl alcohol / 1 h / 20 °C 12.1: potassium carbonate; MgBr2(Et2O); butane-1-thiol / diethyl ether / 2 h / 20 °C 13.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 0.75 h / 0 °C 13.2: 5 h / 75 °C 14.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C 15.1: 3,3-dimethyldioxirane / dichloromethane; acetone / -50 °C View Scheme
参考文献
Martin, Nathaniel; Thomas, Eric J.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 39 p. 7952 - 7964
