4-(2-苯基-1-乙炔)苯甲腈合成路线 （共 64 条）
反应条件
tert.-butylnitrite; trifuran-2-yl-phosphane; palladium diacetate; acetic acid in dimethyl sulfoxide
T=20 - 32°C; Sonogashira coupling; 16 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Chemical Communications, 2011 , vol. 47, # 28 p. 7959 - 7961
反应条件
palladium diacetate; dimethyl sulfoxide
T=20°C; Sonogashira Cross-Coupling; 0.0833333 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
triphenylphosphine; 1-n-butyl-3-methylimidazolium tetrafluoroborate; bis(η3-allyl-μ-chloropalladium(II))
T=130°C; Heck alkynylation; 20 h;
参考文献
Hierso, Jean-Cyrille; Picquet, Michel; Cattey, Helene; Meunier, Philippe
Synlett, 2006 , # 18 p. 3005 - 3008
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -78 - -20 °C
1.3: 78 percent / aq. KHF2 / tetrahydrofuran; hexane / 2 h / -20 - 20 °C
2.1: 69 percent / Cs2CO3 / PdCl2(dppf)*CH2Cl2 / tetrahydrofuran; H2O / 12 h / Heating
View Scheme
参考文献
Molander, Gary A.; Katona, Bryson W.; Machrouhi, Fouzia
Journal of Organic Chemistry, 2002 , vol. 67, # 24 p. 8416 - 8423
反应条件
1,3-dimethyl-imidazolidin-2-one; potassium carbonate; triphenylphosphine; copper(l) chloride
T=120°C; 12 h;
参考文献
Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 518 - 521
反应条件
1: KI / Pd/C / dimethylformamide / 48 h / 130 °C
2: aq. KF / Pd/C / dimethylformamide / 8 h / 130 °C
View Scheme
参考文献
Thathagar, Mehul B.; Rothenberg, Gadi
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 111 - 115
反应条件
copper(l) iodide; 8-hydroxy-quinoline; potassium carbonate in N,N-dimethyl-formamide
T=110°C; 24 h; Inert atmosphere;
参考文献
Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng
RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
反应条件
copper(l) iodide; 8-hydroxy-quinoline; potassium carbonate in N,N-dimethyl-formamide
T=110°C; 24 h; Inert atmosphere;
参考文献
Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng
RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
反应条件
copper(l) iodide; 8-hydroxy-quinoline; potassium carbonate in N,N-dimethyl-formamide
T=110°C; 24 h; Inert atmosphere;
参考文献
Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng
RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
反应条件
triphenylphosphine; 1-n-butyl-3-methylimidazolium hexafluorophosphate; bis(η3-allyl-μ-chloropalladium(II))
T=130°C; Heck alkynylation; 4 h;
参考文献
Hierso, Jean-Cyrille; Boudon, Julien; Picquet, Michel; Meunier, Philippe
European Journal of Organic Chemistry, 2007 , # 4 p. 583 - 587
