1-溴-3-(二氟甲基)苯合成路线 （共 5 条）
反应条件
sulfur(IV) fluoride T=150°C;
参考文献
Journal of the American Chemical Society, , vol. 93, # 19 p. 4715 - 4724
反应条件
1: SnCl2 2: (i) (diazotization), (ii) CuBr View Scheme
参考文献
Zhurnal Organicheskoi Khimii, , vol. 6, # 7 p. 1423 - 1426,1436 - 1439
反应条件
1: SbF3 2: SnCl2 3: (i) (diazotization), (ii) CuBr View Scheme
参考文献
Zhurnal Organicheskoi Khimii, , vol. 6, # 7 p. 1423 - 1426,1436 - 1439
反应条件
(i) (diazotization), (ii) CuBr; Multistep reaction;
参考文献
Zhurnal Organicheskoi Khimii, , vol. 6, # 7 p. 1423 - 1426,1436 - 1439
反应条件
1: 1-bromo-3-difluoromethyl-benzene With n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-78 - 20°C;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51494 A1, 2008 ;
Location in patent: Page/Page column 130 ;
