1: ammonia / methanol / 16 h / 20 °C / Cooling with ice 2: 3,3'-bis-triphenylsilyl BINOL phosphoric acid; tert-butyl Hantzsch ester / benzene / 72 h / 50 °C / Inert atmosphere; Sealed tube 3: triethylamine / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere 4: formic acid; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 50 °C View Scheme

8-hydroxy-quinoline; oxygen; anhydrous copper acetate; potassium carbonate T=140°C; P=760.051 Torr; 24 h;