3,4-二甲氧基-5-羟基苯甲醛合成路线 （共 37 条）
反应条件
1: 58 percent / KI, K2CO3 / acetone / 0.25 h / Heating
2: 38 percent / ammonium acetate / 1 h / Heating
3: AlH3 / tetrahydrofuran / 0.5 h / Heating
View Scheme
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 881 - 888
反应条件
1: 78 percent / KI, K2CO3 / acetone / 0.25 h / Heating
2: 53 percent / ammonium acetate / 1 h / Heating
3: AlH3 / tetrahydrofuran / 0.5 h / Heating
View Scheme
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 881 - 888
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
3: sodium hydroxide / methanol / 3 h / 20 °C
4: potassium carbonate / acetone
5: trichlorophosphate / 3.5 h / 0 - 80 °C
6: potassium hydroxide / methanol; water / 24.5 h / 0 - 20 °C
7: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C
View Scheme
参考文献
Kuo, Ping-Chung; Chen, Yi-Hsien; Leu, Yann-Lii; Huang, Chieh-Hung; Liao, Yu-Ren; Lee, E.-Jian; Yang, Mei-Lin; Wu, Tian-Shung
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 4 p. 557 - 561
反应条件
potassium carbonate; potassium iodide in ethanol
2 h; Heating;
参考文献
Planchenault, Denis; Dhal, Robert; Robin, Jean-Pierre
Tetrahedron, 1995 , vol. 51, # 5 p. 1395 - 1404
反应条件
18-crown-6 ether; potassium carbonate in tetrahydrofuran
Substitution; Heating;
参考文献
Jarevang, Tomas; Nilsson, Marie-Charlotte; Wallstedt, Anna; Odham, Goeran; Sterner, Olov
Phytochemistry, 1998 , vol. 48, # 5 p. 893 - 896
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 20 °C
2.2: 2 h / 20 °C
3.1: potassium hydroxide / methanol / 48 h / 20 °C
4.1: tin(IV) chloride / dichloromethane / 20 °C
View Scheme
参考文献
Kuo, Ping-Chung; Chen, Yi-Hsien; Leu, Yann-Lii; Huang, Chieh-Hung; Liao, Yu-Ren; Lee, E.-Jian; Yang, Mei-Lin; Wu, Tian-Shung
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 4 p. 557 - 561
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
3: sodium hydroxide / methanol / 3 h / 20 °C
4: potassium carbonate / acetone
5: trichlorophosphate / 3.5 h / 0 - 80 °C
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378
